CD4 T cell differentiation in type 1 diabetes
نویسندگان
چکیده
منابع مشابه
t-helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes
t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
متن کاملt helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes
t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
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Pulmonary infection of mice with Aspergillus fumigatus induces concurrent T helper type 1 (Th1) and Th17 responses that depend on Toll-like receptor/MyD88 and Dectin-1, respectively. However, the mechanisms balancing Th1 and Th17 CD4 T cell populations during infection remain incompletely defined. In this study, we show that Dectin-1 deficiency disproportionally increases Th1 responses and decr...
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This study aimed to investigate the role of Pim-1 kinase in the regulation of naïve CD4+T cell differentiation. Naive CD4+T cells were isolated from the spleen of the mice and treated with different cytokines and Pim-1 kinase inhibitor. The expression of T-bet, GATA3, FOXP3 and RORγt proteins in naïve CD4+T cells was detected by Western blot analysis. The expression of cytokines IL-4, TGF-β, IF...
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Reactive oxygen species (ROS) play prominent roles in numerous biological systems. While classically expressed by neutrophils and macrophages, CD4 T cells also express NADPH oxidase (NOX), the superoxide-generating multisubunit enzyme. Our laboratory recently demonstrated that superoxide-deficient nonobese diabetic (NOD.Ncf1(m1J)) mice exhibited a delay in type 1 diabetes (T1D) partially due to...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2015
ISSN: 0009-9104
DOI: 10.1111/cei.12672